As pharmacological interventions, analgesics, antihistamines, and decongestants have been applied as mono- and combination therapy. The primary goal of the treatment is a reduction in duration and severity of the symptoms by non-pharmacological and pharmacological interventions. Hence, people usually recover in seven or ten days. These symptoms are generally self-limited. The common cold, an acute upper respiratory viral infection, is a mild illness that typically presents with nasal congestion, rhinorrhea, sour throat, cough, headache, and fever. In conclusion, jelly can be a patient-centered formulation with comparable bioavailability to syrup. In two IR tablets, GMRs of AUC 0-t were in a range of 0.55–0.95 indicating a tendency of lower absorption than the syrup and jellies. However, Jelly-S and Jelly-H showed 0.82–1.05 of the geometric mean ratios (GMRs) of AUC 0-t for all four drugs compared to the syrup suggesting comparable absorption. When administered orally to beagle dogs, all five formulations were determined not to be bioequivalent. The dissolution rates from the jellies decreased with increasing pH, which resulted in the slowest dissolution in pH 6.8 compared to the syrup and IR tablets. All the formulations exhibited more than 80% dissolution rate within 2 h even though the syrup, Jelly-S, and Tablet-S showed higher 30-min dissolution compared to Jelly-H and Tablet-H. In vitro dissolution and in vivo absorption of the four drugs in the jellies were compared with other conventional formulations, a syrup and two types of immediate-release (IR) tablets with different hardness, Tablet-S (15 kPa) and Tablet-H (20 kPa). Jelly-S and Jelly-H were fabricated using carrageenan and locust bean gum in the absence and presence of xanthan gum, respectively. To evaluate the effect of jelly formulation on the bioavailability of cold medicines, two types of jellies were prepared for a fixed-dose combination of acetaminophen (AAP), chlorpheniramine maleate (CPM), dextromethorphan hydrobromide (DMH), and dl-methylephedrine hydrochloride (MEH). Animal Sci.Jellies for oral administration have been suggested as alternative dosage forms to conventional tablets for improved palatability and compliances for pediatric and geriatric patients. Standards Carbohydrates and Oligosaccharides ĭ-Lactose is a disaccharide sugar present in milk that contributes to the overall health in humans, mammals and insects alike. Β-D-galactopyranosyl-(1→4)-D-glucose Lactose (+)-Lactose AHL Aletobiose D-(+)-Lactose DCL 15 DCl 11 Dilactose Fast-Flo Lactose Fast-flo Flowlac 100 Galactinum Granulac 140 Granulac 140M Granulac 70 Inhalac 70 Lactin Lactin (carbohydrate) Lactobiose Lactohale 100 Lactohale 200 Lactohale 300 Lactose Edible 90 Lactose Fast-flo Lactose Anhydride Lactose Anhydrous Milk Sugar Nonpareil 107 Osmolactan Pharmatosa DCL 21 Pharmatose 21 Pharmatose 325M Pharmatose DCL 15 PrenoLakt Prismalac Respitose ML 001 Respitose ML 003 Respitose ML 006 Respitose SV 003 Saccharum Lactin Sachelac Sorbalac 400 Sorbolac 400 Spherolac Super-Tab SuperTab 11SD SuperTab 21AN Tablettose Tablettose 70 Tablettose 80 Variolac 960 Zeparox EPĪqueous Acid (Sparingly), Methanol (Very Slightly, Heated, Sonicated), Water (Sl